Remdesivir: Identification, Determination and Spectral Study
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https://doi.org/10.48112/bcs.v2i2.444Abstract
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Corona viruses resist many antiviral agents which reduces the antiviral therapies. Remdesivir is an antiviral drug efficient against single-stranded RNA viruses. Analytical determinations of this drug are very benefit in selecting the correct dose and getting real information and formulas of this compound. In this work, remdesivir has been identified at 239 nm in aqueous alkaline (1M NaOH), at 245 nm in ethanol, and at 246 nm. in methanol, it has also been followed at 239 nm using the alkaline medium and determined in injection, the linearity range was from 1to 60 µg/ml with molar absorptivity 2.036×104 l.mol-1.cm-1, and Sandell’s sensitivity index is 0.0295 µg.cm-2, LOD is 0.2613 and LOQ is 0.871 µg/mL. I. R spectrum of solid remdesivir shows band at 1639.96 cm -1 due to the carbonyl group and at 3350.79 cm-1refer to the hydroxy group adjacent to NH2 group which appears at about 3300 cm-1, the aromatic was identified at 1660-2000 cm-1 and C-O of ester at 1153cm-1. These bands in the alkaline medium were slightly shifted to be 1637 cm -1 due to carbonyl group and at 3318 cm-1refer to hydroxy group adjacent to NH2 group which appeared at about 3264 cm-1, the aromatic was identified at 2131 cm-1, and C-O of ester at 1379cm-1.
Keywords:
Remdesivir, identification, determination, spectral studyReferences
Abdel Moneim, M. M., Kamal, M. F., & Hamdy, M. M. (2021). Rapid sensitive bioscreening of remdesivir in COVID-19 medication: Selective drug determination in the presence of six co-administered therapeutics. Reviews in Analytical Chemistry, 40(1), 323-333. https://doi.org/10.1515/revac-2021-0141
Al-Tannak, N. F., Novotny, L., & Alhunayan, A. (2020). Remdesivir—bringing hope for COVID-19 treatment. Scientia Pharmaceutica, 88(2), 29. https://doi.org/10.3390/scipharm88020029
Alvarez, J. C., Moine, P., Etting, I., Annane, D., & Larabi, I. A. (2020). Quantification of plasma remdesivir and its metabolite GS-441524 using liquid chromatography coupled to tandem mass spectrometry. Application to a Covid-19 treated patient. Clinical Chemistry and Laboratory Medicine (CCLM), 58(9), 1461-1468. https://doi.org/10.1515/cclm-2020-0612
Attia, T. Z., Boushra, J. M., Abdel Hakiem, A. F., Lashien, A. S., & Noureldeen, D. A. (2022). Spectrofluorimetric determination of the anti‐Covid 19 agent, remdesivir, in vials and spiked human plasma. Luminescence, 37(7), 1192-1199. https://doi.org/10.1002/bio.4274
Avataneo, V., De Nicolò, A., Cusato, J., Antonucci, M., Manca, A., Palermiti, A., ... & D’Avolio, A. (2020). Development and validation of a UHPLC-MS/MS method for quantification of the prodrug remdesivir and its metabolite GS-441524: a tool for clinical pharmacokinetics of SARS-CoV-2/COVID-19 and Ebola virus disease. Journal of Antimicrobial Chemotherapy, 75(7), 1772-1777. https://doi.org/10.1093/jac/dkaa152
Camões, M. F., & Anes, B. (2019). Hydrated Protons. Reference Module in Chemistry, Molecular Sciences and Chemical Engineering. https://doi.org/10.1016/B978-0-12-409547-2.14298-2
Christian, G. D., Dasgupta, P. K., & Schug, K. A. (2013). Analytical chemistry. John Wiley & Sons.
Darwish, I. A., Khalil, N. Y., Darwish, H. W., Alzoman, N. Z., & Al-Hossaini, A. M. (2022). Synthesis, spectroscopic and computational characterization of charge transfer complex of remdesivir with chloranilic acid: Application to development of novel 96-microwell spectrophotometric assay. Journal of Molecular Structure, 1263, 133104. https://doi.org/10.1016/j.molstruc.2022.133104
Eastman, R. T., Roth, J. S., Brimacombe, K. R., Simeonov, A., Shen, M., Patnaik, S., & Hall, M. D. (2020). Remdesivir: a review of its discovery and development leading to emergency use authorization for treatment of COVID-19. ACS central science, 6(5), 672-683. https://doi.org/10.1021/acscentsci.0c00489
Elmansi, H., Ibrahim, A. E., Mikhail, I. E., & Belal, F. (2021). Green and sensitive spectrofluorimetric determination of Remdesivir, an FDA approved SARS-CoV-2 candidate antiviral; application in pharmaceutical dosage forms and spiked human plasma. Analytical Methods, 13(23), 2596-2602. https://doi.org/10.1039/D1AY00469G
Emam, A. A., Abdelaleem, E. A., Abdelmomen, E. H., Abdelmoety, R. H., & Abdelfatah, R. M. (2022). Rapid and ecofriendly UPLC quantification of Remdesivir, Favipiravir and Dexamethasone for accurate therapeutic drug monitoring in Covid-19 Patient’s plasma. Microchemical Journal, 179, 107580. https://doi.org/10.1016/j.microc.2022.107580
Lamb, Y. N. (2020). Remdesivir: first approval. Drugs, 80, 1355-1363. https://doi.org/10.1007/s40265-020-01378-w
Murphy, B. G., Perron, M., Murakami, E., Bauer, K., Park, Y., Eckstrand, C., ... & Pedersen, N. C. (2018). The nucleoside analog GS-441524 strongly inhibits feline infectious peritonitis (FIP) virus in tissue culture and experimental cat infection studies. Veterinary microbiology, 219, 226-233. https://doi.org/10.1016/j.vetmic.2018.04.026
Noureldeen, D. A., Boushra, J. M., Lashien, A. S., Hakiem, A. F. A., & Attia, T. Z. (2022). Novel environment friendly TLC-densitometric method for the determination of anti-coronavirus drugs “Remdesivir and Favipiravir”: Green assessment with application to pharmaceutical formulations and human plasma. Microchemical Journal, 174, 107101. https://doi.org/10.1016/j.microc.2021.107101
Pashaei, Y. (2020). Analytical methods for the determination of remdesivir as a promising antiviral candidate drug for the COVID-19 pandemic. Drug Discoveries & Therapeutics, 14(6), 273-281. https://doi.org/10.5582/ddt.2020.03097
Rizk, M., Sultan, M. A., Tawfik, B. M., & El-Eryan, R. T. (2022). Highly Sensitive and Selective Sensing Probe for Determination of Anti-Covid-19 Remdesvir: Application to Pharmaceutical Dosage Form and Biological Fluids. Journal of The Electrochemical Society, 169(2), 026522. https://doi.org/10.1149/1945-7111/ac53ca
Sahakijpijarn, S., Moon, C., Koleng, J. J., Christensen, D. J., & Williams Iii, R. O. (2020). Development of remdesivir as a dry powder for inhalation by thin film freezing. Pharmaceutics, 12(11), 1002. https://doi.org/10.3390/pharmaceutics12111002
Sahakijpijarn, S., Moon, C., Warnken, Z. N., Maier, E. Y., DeVore, J. E., Christensen, D. J., ... & Williams III, R. O. (2021). In vivo pharmacokinetic study of remdesivir dry powder for inhalation in hamsters. International Journal of Pharmaceutics: X, 3, 100073. https://doi.org/10.1016/j.ijpx.2021.100073
Skaggs, C., Zimmerman, H., Manicke, N., & Kirkpatrick, L. (2022). Development and validation of a paper spray mass spectrometry method for the rapid quantitation of remdesivir and its active metabolite, GS-441524, in human plasma. Journal of Mass Spectrometry and Advances in the Clinical lab, 25, 27-35. https://doi.org/10.1016/j.jmsacl.2022.06.001
Yan, V. C., & Muller, F. L. (2020). Advantages of the parent nucleoside GS-441524 over remdesivir for Covid-19 treatment. ACS medicinal chemistry letters, 11(7), 1361-1366. https://doi.org/10.1021/acsmedchemlett.0c00316
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