Association of ADIPOQ (rs 2241766) Gene Polymorphism with Type 2 Diabetes Mellitus Patients

A Case-Control Study

Authors

  • Ameer Abbas Department of Chemistry, College of Education, University of Al-Qadisiyah, Al-Diwaniyah – Iraq
  • Wisam Hoidy Department of Chemistry, College of Education, University of Al-Qadisiyah, Al-Diwaniyah – Iraq

DOI:

https://doi.org/10.48112/bcs.v1i2.124

Abstract

Abstract Views: 201

The adiponectin gene (ADIPOQ) is the main genetic determinant of plasma adiponectin amounts from (30 - 70%) of the inherited genetic components. Multiple nucleotide polymorphisms (SNPs) rs 2241766 for the ADIPOQ gene correlate with metabolic syndromes such as insulin resistance, abdominal obesity, impaired glucose tolerance, hyperlipidemia, hypertension, rapid glucose excess, and plasma adiponectin level. A polymorphism study was conducted based on PCR 2241766 in Al-Diwaniyah city in Iraq, and this study included (300) people aged (30-45) years who were distributed into two groups, the first group (G1) included (150) control, and the second group (G2) included (150) type 2 diabetes mellitus patients. The purpose of the current study was to reveal the ADIPOQ polymorphism and its role in the pathophysiology of type 2 diabetes mellitus. The overall genotype of the ADIPOQ rs2241766 gene was significantly different between the type 2 diabetes mellitus patients (G2) and control (G1) for the genotype GG (χ2 = 13.45, p-value = 0.002), G allele (χ2 = 10.324, p-value = 0.001), and TG & TT compared to the GG genotype (χ2 = 13.266, p-value = 0.0001). In conclusion, the results of the genotype and allele distribution of ADIPOQ rs2241766 gene in type 2 diabetes patients group showed that there is an association between ADIPOQ rs2241766 gene and type 2 diabetes mellitus.

Keywords:

Type 2 diabetes mellitus, ADIPOQ, Polymorphism

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References

Owusu Adjah, E. S., Bellary, S., Hanif, W., Patel, K., Khunti, K., & Paul, S. K. (2018). Prevalence and incidence of complications at diagnosis of T2DM and during follow-up by BMI and ethnicity: a matched case–control analysis. Cardiovascular diabetology, 17(1), 1-9. https://doi.org/10.1186/s12933-018-0712-1

Mofarrah, M., Ziaee, S., Pilehvar-Soltanahmadi, Y., Zarghami, F., Boroumand, M., & Zarghami, N. (2016). Association of KALRN, ADIPOQ, and FTO gene polymorphism in type 2 diabetic patients with coronary artery disease: possible predisposing markers. Coronary artery disease, 27(6), 490-496. https://doi.org/10.1097/MCA.0000000000000386

Bigagli, E., & Lodovici, M. (2019). Circulating oxidative stress biomarkers in clinical studies on type 2 diabetes and its complications. Oxidative Medicine and Cellular Longevity, 2019. https://doi.org/10.1155/2019/5953685

Davis, S. K., Xu, R., Gebreab, S. Y., Riestra, P., Gaye, A., Khan, R. J., ... & Bidulescu, A. (2015). Association of ADIPOQ gene with type 2 diabetes and related phenotypes in African American men and women: the Jackson Heart Study. BMC genetics, 16(1), 1-13. https://doi.org/10.1186/s12863-015-0319-4

Farr, J. N., & Khosla, S. (2016). Determinants of bone strength and quality in diabetes mellitus in humans. Bone, 82, 28-34. https://doi.org/10.1016/j.bone.2015.07.027

Fiaschi, T. (2019). Mechanisms of adiponectin action. International Journal of Molecular Sciences, 20(12), 28-94. https://doi.org/10.3390/ijms20122894

Hoidy, W. H., Jaber, F. A., & Al-Askiry, M. A. (2019). Association of CYP1A1 rs1048943 polymorphism with prostate cancer in Iraqi men patients. Asian Pacific journal of Cancer Prevention: APJCP, 20(12), 3839. https://dx.doi.org/10.31557%2FAPJCP.2019.20.12.3839

Hussain, A., & Ali, I. (2016). Diabetes mellitus in Pakistan: A major public health concern. Archives of Pharmacy Practice, 7(1), 30-33.

Hussain, M. K., Deli, F. A., Algenabi, A. H. A., & Abdul-Rudha, K. H. (2018). Adiponectin gene polymorphisms as a predictor for development of type 2 diabetes mellitus in Iraqi population. Gene, 662, 118-122. https://doi.org/10.1016/j.gene.2018.03.087

Jabir, F. A., & Hoidy, W. H. (2018). Pharmacogenetics as personalized medicine: Association investigation of SOD2 rs4880, CYP2C19 rs4244285, and FCGR2A rs1801274 polymorphisms in a breast cancer population in Iraqi women. Clinical Breast Cancer, 18(5), e863-e868. https://doi.org/10.1016/j.clbc.2018.01.009

Kao, K. T., & Sabin, M. A. (2016). Type 2 diabetes mellitus in children and adolescents. Australian Family Physician, 45(6), 401-406.

Mezza, T., Cinti, F., Cefalo, C. M. A., Pontecorvi, A., Kulkarni, R. N., & Giaccari, A. (2019). β-cell fate in human insulin resistance and type 2 diabetes: a perspective on islet plasticity. Diabetes, 68(6), 1121-1129. https://doi.org/10.2337/db18-0856

Murray, C. E., & Coleman, C. M. (2019). Impact of diabetes mellitus on bone health. International Journal of Molecular Sciences, 20(19), 4873. https://doi.org/10.3390/ijms20194873

Tura, A., Göbl, C., Moro, E., & Pacini, G. (2017). Insulin resistance and beta-cell dysfunction in people with prediabetes according to criteria based on glycemia and glycosylated hemoglobin. Endocrine Journal, 64(1), 117-122. https://doi.org/10.1507/endocrj.EJ16-0298

Wang, Z., Diao, J., Yue, X., & Zhong, J. (2019). Effects of ADIPOQ polymorphisms on individual susceptibility to coronary artery disease: a meta-analysis. Adipocyte, 8(1), 137-143. https://doi.org/10.1080/21623945.2019.1595270

Yaribeygi, H., Farrokhi, F. R., Butler, A. E., & Sahebkar, A. (2019). Insulin resistance: Review of the underlying molecular mechanisms. Journal of cellular physiology, 234(6), 8152-8161. https://doi.org/10.1002/jcp.27603

Zheng, Y., Ley, S. H., & Hu, F. B. (2018). Global aetiology and epidemiology of type 2 diabetes mellitus and its complications. Nature Reviews Endocrinology, 14(2), 88-98. https://doi.org/10.1038/nrendo.2017.151

Association of ADIPOQ (rs 2241766) Gene Polymorphism with Type 2 Diabetes Mellitus Patients

Published

2022-04-01

How to Cite

Abbas, A., & Hoidy, W. (2022). Association of ADIPOQ (rs 2241766) Gene Polymorphism with Type 2 Diabetes Mellitus Patients: A Case-Control Study. Biomedicine and Chemical Sciences, 1(2), 88–92. https://doi.org/10.48112/bcs.v1i2.124

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