Analytical Studies of New Azo dye and the Diminished in their Biological Activity by Complexation with Zinc
DOI:
https://doi.org/10.5281/zenodo.16652335Abstract
Abstract Views: 576
Azo dye (1), that characterized (Z)-5-amino-2-(((4-(5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl) phenyl) sulfonyl) diazenyl) phenol) was prepared. Then characterized using m.p., IR, UV-visible, mass spectrum and elemental analysis (CHN). Analytical studies approved on this dye; which showed high solubility in ethanol and gave three isopiestic points, that when studying the pH effect in a range of buffer solutions. The protonation constants pKb1 and pKb2 of nitrogen atom and the ionization constant pKa of OH-group were equal to 3.4, 7.26 and 10.5 respectively. These results indicated the suggested ionization scheme in acidic and basic media. However, due to recommend the new azo dye as novel medicine or chemical sanitizer especially in dual infection. the complex of azo dye (1) with Zn was decreased the biological activity of dye.
Keywords:
Azo dye, Biological activity, Elemental analysis, Haemolysis effects, Ionization constantsReferences
Ali, A. A., Fahad, T. A., & Al-muhsin, A. A. (2020, November). Preparation and Spectroanalytical Studies of Two New Azo Dyes Based on Luminol. In IOP Conference Series: Materials Science and Engineering (Vol. 928, No. 5, p. 052007). IOP Publishing. https://doi.org/10.1088/1757-899x/928/5/052007
Ali, H. M., Majeed, H. A. A., Hussain, A. A., & Hashim, R. (2009). Analytical and Theoretical Studies of Some Diazo Dyes. Journal of Global Pharma Technology, 11(04).
Ali, H., Majeed, H. A. S. A., Al-Asadi, I., Abdulredha, A., & Hussain, A. (2018). Structures effect of two azo dyes associated with their antimicrobial activity. Journal of Chemical, Biological and Physical Sciences, 8, 171-185.
Ali, H., Majeed, H., & Hussain, A. (2017). Synthesis, Analytical and Theoretical studies of (Z)-4amino-3-hydroxy-2-((4-(N-(5-methyl isoxazol-3yl) sulfamoyl) phenyl) diazenyl) naphthalene-1-Sulfonic Acid. Journal of Natural Sciences Research, 7, 81-88.
Eady, S. J., Ali, H. M., & Al-Shawi, A. A. (2018). Preparation of novel Azo Dyes as a new anti-Human Breast Cancer MDA-MB231 Cells and study its association with DNA. Journal of Basrah Researches (Sciences), 29, 1-11.
Farghaly, T. A., & Abdallah, Z. A. (2008). Synthesis, azo-hydrazone tautomerism and antitumor screening of N-(3-ethoxycarbonyl-4, 5, 6, 7-tetrahydro-benzo [b] thien-2-yl)-2-arylhydrazono-3-oxobutanamide derivatives. Arkivoc, 17, 295-305.
Fayadh, R. H., Ali, A. A., & Al Jabri, F. M. (2015). Synthesis and identification symmetrically azo dyes derived from sulfa compounds and spectrophotometric study of nickel (II) complexes with prepared dyes. International Journal of Engineering and Technical Research (IJETR), 3, 25-28.
Fayadh, R. H., Ali, A. A., & Al-Jabri, F. M. (2015). The synthesis and identification azo dyes derived from mercuried sulfa compounds and used their as indicator of acid-base. Research Journal of Pharmaceutical Biological and Chemical Sciences, 6(3), 1278-1285.
Kirkan, B., & Gup, R. (2008). Synthesis of new azo dyes and copper (II) complexes derived from barbituric acid and 4-aminobenzoylhydrazone. Turkish Journal of Chemistry, 32(1), 9-17.
Majeed, H. (2013). Synthesis, Characterization, and study of the Spectral and Electronic Properties of a New Azo Dyes Compounds. University of Thi-Qar Journal of Science, 4(1), 91-101.
Majeed, H., Al-Ahmad, A., & Hussain, K. (2011). The preparation, characterization and the study of the linear optical properties of a new azo compound. Journal of Basrah Researches ((Sciences)), 37(2).
Mutar, M. M., & Ali, H. M. (2021, November). Preparation, Characterization and Analytical Studies of novel Azo dyes and Diazo dyes. In Journal of Physics: Conference Series (Vol. 2063, No. 1, p. 012023). IOP Publishing. https://doi.org/10.1088/1742-6596/2063/1/012023
Otutu, J. O. (2013). Synthesis and application of azo dyes derived from 2-Amino-1, 3, 4-thiadiazole-2-thiol on polyester fibre. International Journal of Research and Reviews in Applied Sciences, 15(2), 292-296.
Primo, F. T., & Fröhlich, P. E. (2005). Celecoxib identification methods. Acta Farmaceutica Bonaerense, 24(3), 421.
Thangavelu, R., Devi, P. G., Gopi, M., & Mustaffa, M. M. (2013). Management of Eumusae leaf spot disease of banana caused by Mycosphaerella eumusae with Zimmu (Allium sativum× Allium cepa) leaf extract. Crop protection, 46, 100-105. https://doi.org/10.1016/j.cropro.2012.12.022
Xian-Guo, H., & Ursula, M. (1994). Determination of hemolysis against fresh sheep RBCs. J. Ethnopharmacol, 43, 173-177.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Biomedicine and Chemical Sciences
This work is licensed under a Creative Commons Attribution 4.0 International License.
