Medicinal Plants and their Phytochemical
A Critical Look on the Potential Benefits of Medicinal Plants on Cardiovascular Disease
DOI:
https://doi.org/10.5281/zenodo.15777143Abstract
Abstract Views: 385
Throughout human history, from ancient civilisations to the present day, individuals have sought the healing properties of medicinal plants, commonly referred to as medicinal herbs. These natural botanical resources are used for therapeutic purposes owing to their efficacy, widespread availability in various regions across the globe, and cost-effectiveness. This paper helps to focuses on medicinal plants that help treat cardiovascular diseases. Phytochemicals are the key botanical components that allow plants to have secondary metabolites that help protect them from environmental hazards and cardiovascular disease. There are several classifications of phytochemicals, some of which include phenols, flavonoids, nonflavonoids, and alkaloids. The purpose of this research is to identify plant species rich in phytochemicals that may help treat cardiac-related diseases. The plants, seeds and plant extracts mentioned include banana, hawthorn, flaxseed, spinach, arjuna and grapefruit extracts. These plants possess one or more properties of antioxidant, anti-inflammatory, cardioprotective, hypolipidemic, antihepatotoxic, and reduced dietary fat absorption. They have also been found to contain phytochemicals such as flavonoids, phenols, tannins, polyphenols, phenols, and flavonoids, which can be found in a variety of geographical locations across the world.
Keywords:
Anti-inflammatories, Antioxidants, Cardio-protective properties, Cardiovascular diseases, Medicinal plants, PhytochemicalsReferences
Adili, R., Hawley, M. & Holinstat, M. (2018) ‘Regulation of platelet function and thrombosis by omega-3 and omega-6 polyunsaturated fatty acids’, Prostaglandins & Other Lipid Mediators, 139, pp. 10–18. https://doi.org/10.1016/j.prostaglandins.2018.09.005
Ahmed, A., Tariq, A. & Habib, S. (2020) ‘Interactive biology of auxins and phenolics in plant environment’, Plant Phenolics in Sustainable Agriculture: Volume 1, pp. 117–133.
Alique, M., Luna, C., Carracedo, J., & Ramírez, R. (2015). LDL biochemical modifications: a link between atherosclerosis and aging. Food & nutrition research, 59(1), 29240. https://doi.org/10.3402/fnr.v59.29240
Alizadehasl, A., Sepasi, F., Azarfarin, R., & Ghaffari, S. (2008). Hypokalemia, arrhythmias and early outcomes in acute myocardial infarction. Research Journal of Biological Sciences, 9(3), 1130-2.
Amalraj, A. & Gopi, S. (2017) ‘Medicinal properties of Terminalia arjuna (Roxb.) Wight & Arn.: A review’, Journal of Traditional and Complementary Medicine, 7(1), pp. 65–78. https://doi.org/10.1016/j.jtcme.2016.02.003
Aune, D., Giovannucci, E., Boffetta, P., Fadnes, L. T., Keum, N., Norat, T., ... & Tonstad, S. (2017). Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality—a systematic review and dose-response meta-analysis of prospective studies. International journal of epidemiology, 46(3), 1029-1056. https://doi.org/10.1093/ije/dyw319
Bagchi, D., Sen, C. K., Ray, S. D., Das, D. K., Bagchi, M., Preuss, H. G., & Vinson, J. A. (2003). Molecular mechanisms of cardioprotection by a novel grape seed proanthocyanidin extract. Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 523, 87-97. https://doi.org/10.1016/s0027-5107(02)00324-x
Balentine, D.A., Wiseman, S.A. & Bouwens, L.C. (1997) ‘The chemistry of tea flavonoids.’, Critical reviews in food science and nutrition, 37(8), pp. 693–704. https://doi.org/10.1080/10408399709527797.
Balunas, M.J. & Kinghorn, A.D. (2005) ‘Drug discovery from medicinal plants.’, Life sciences, 78(5), pp. 431–441. https://doi.org/10.1016/j.lfs.2005.09.012.
Bisen, P., Chaturvedi, A., Ganeshpurkar, A., & Dubey, N. (2020). Cardioprotective effect of ethanolic extract of leaves of amaranthus cruentus in isoprenaline-induced myocardial infarction in rats. Free Radicals and Antioxidants, 10(1), 24-28. https://doi.org/10.5530/fra.2020.1.5
Bohlmann, J., Meyer-Gauen, G. & Croteau, R. (1998) ‘Plant terpenoid synthases: molecular biology and phylogenetic analysis.’, Proceedings of the National Academy of Sciences of the United States of America, 95(8), pp. 4126–4133. https://doi.org/10.1073/pnas.95.8.4126
Bruno, M.J., Koeppe, R.E. & Andersen, O.S. (2007) ‘Docosahexaenoic acid alters bilayer elastic properties’, Proceedings of the National Academy of Sciences, 104(23), pp. 9638–9643. https://doi.org/10.1073/pnas.0701015104
Cao, J., Chen, W., Zhang, Y., Zhang, Y., & Zhao, X. (2010). Content of selected flavonoids in 100 edible vegetables and fruits. Food science and technology research, 16(5), 395-402.
Cerrato, A., Cannazza, G., Capriotti, A. L., Citti, C., La Barbera, G., Laganà, A., ... & Cavaliere, C. (2020). A new software-assisted analytical workflow based on high-resolution mass spectrometry for the systematic study of phenolic compounds in complex matrices. Talanta, 209, 120573.
Chis, I. C., Ungureanu, M. I., Marton, A., Simedrea, R., Muresan, A., Postescu, I. D., & Decea, N. (2009). Antioxidant effects of a grape seed extract in a rat model of diabetes mellitus. Diabetes and Vascular Disease Research, 6(3), 200-204.
Crozier, A., Jaganath, I.B. & Clifford, M.N. (2006) ‘Phenols, Polyphenols and Tannins: An Overview’, in Plant Secondary Metabolites, pp. 1–24. https://doi.org/10.1002/9780470988558.ch1
Crozier, A., Jaganath, I.B. & Clifford, M.N. (2009) ‘Dietary phenolics: chemistry, bioavailability and effects on health’, Natural product reports, 26(8), pp. 1001–1043.
Dahal, M. (2020). Effect of roasting on bioactive and antinutritional components of flaxseed (Linum Usitatissimum) by Merina Dahal Department of Nutrition and Dietetics Central Campus of Technology Institute of Science and Technology Tribhuvan University, Nepal 2019 (Doctoral dissertation, Department of Nutrition and Dietetics Central Campus of Technology Institute of Science and Technology Tribhuvan University, Nepal October, 2019).
Dai, J. and Mumper, R.J. (2010) ‘Plant phenolics: extraction, analysis and their antioxidant and anticancer properties.’, Molecules (Basel, Switzerland), 15(10), pp. 7313–7352. https://doi.org/10.3390/molecules15107313
Dar, R. A., Shahnawaz, M., Rasool, S., & Qazi, P. H. (2017). Natural product medicines: A literature update. J phytopharmacol, 6(6), 349-351.
del Pilar Vilariño, M. & Ravetta, D.A. (2008) ‘Tolerance to herbivory in lupin genotypes with different alkaloid concentration: Interspecific differences between Lupinus albus L. and L. angustifolius L.’, Environmental and experimental botany, 63(1–3), pp. 130–136.
Delmas, D., Jannin, B. & Latruffe, N. (2005) ‘Resveratrol: preventing properties against vascular alterations and ageing.’, Molecular nutrition & food research, 49(5), pp. 377–395. https://doi.org/10.1002/mnfr.200400098
DiNicolantonio, J.J. & OKeefe, J. (2019) ‘Importance of maintaining a low omega-6/omega-3 ratio for reducing platelet aggregation, coagulation and thrombosis.’, Open heart, 6(1), p. e001011. https://doi.org/10.1136/openhrt-2019-001011
Ekor, M. (2014) ‘The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety.’, Frontiers in pharmacology, 4, p. 177. https://doi.org/10.3389/fphar.2013.00177
Fale, S. K., Umekar, M. J., Das, R., & Alaspure, M. (2022). A comprehensive study of herbal cosmetics prepared from flaxseed. Multidiscip. Int. Res. J. Gujarat Technol. Univ, 4, 106-112.
Gaitan, E., Lindsay, R. H., Reichert, R. D., INGBAR, S. H., Cooksey, R. C., Legan, J., ... & KUBOTA, K. (1989). Antithyroid and goitrogenic effects of millet: role of C-glycosylflavones. The Journal of Clinical Endocrinology & Metabolism, 68(4), 707-714. https://doi.org/10.1210/jcem-68-4-707
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., ... & Martín, C. (2020). Pathophysiology of type 2 diabetes mellitus. International journal of molecular sciences, 21(17), 6275. https://doi.org/10.3390/ijms21176275
Gibson, E. L., Wardle, J., & Watts, C. J. (1998). Fruit and vegetable consumption, nutritional knowledge and beliefs in mothers and children. Appetite, 31(2), 205-228. https://doi.org/10.1006/appe.1998.0180
Gopinath, K., Gowri, S., Karthika, V., & Arumugam, A. (2014). Green synthesis of gold nanoparticles from fruit extract of Terminalia arjuna, for the enhanced seed germination activity of Gloriosa superba. Journal of Nanostructure in Chemistry, 4, 1-11.
Goswami, M., Chaturvedi, P., Sonwani, R. K., Gupta, A. D., Singhania, R. R., Giri, B. S., ... & Singh, R. S. (2020). Application of Arjuna (Terminalia arjuna) seed biochar in hybrid treatment system for the bioremediation of Congo red dye. Bioresource Technology, 307, 123203. https://doi.org/10.1016/j.biortech.2020.123203
Goyal, A., Sharma, V., Upadhyay, N., Gill, S., & Sihag, M. (2014). Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of food science and technology, 51, 1633-1653. https://doi.org/10.1007/s13197-013-1247-9
Hasler, C.M. & Blumberg, J.B. (1999) ‘Introduction1’, The Journal of Nutrition, 129(3), pp. 756S-757S. https://doi.org/10.1093/jn/129.3.756S
Hazra, B., Biswas, S. & Mandal, N. (2008) ‘Antioxidant and free radical scavenging activity of Spondias pinnata.’, BMC complementary and alternative medicine, 8, p. 63. https://doi.org/10.1186/1472-6882-8-63
Ivey, K. L., Hodgson, J. M., Croft, K. D., Lewis, J. R., & Prince, R. L. (2015). Flavonoid intake and all-cause mortality. The American journal of clinical nutrition, 101(5), 1012-1020. https://doi.org/10.3945/ajcn.113.073106
Jackson, S.P. (2007) ‘The growing complexity of platelet aggregation.’, Blood, 109(12), pp. 5087–5095. https://doi.org/10.1182/blood-2006-12-027698
Jahan, N., Ali, S., Asi, M. R., & Akhtar, A. (2012). Cardioprotective Potential of Gemmomodified Extract of Terminalia arjuna against Chemically Induced Myocardial Injury in Rabbits. Pakistan veterinary journal, 32(2).
Javidi, A., Mozaffari-Khosravi, H., Nadjarzadeh, A., Dehghani, A., & Eftekhari, M. H. (2016). The effect of flaxseed powder on insulin resistance indices and blood pressure in prediabetic individuals: A randomized controlled clinical trial. Journal of Research in Medical Sciences, 21(1), 70. https://doi.org/10.4103/1735-1995.189660
Jayachandran, K. S., Khan, M., Selvendiran, K., Devaraj, S. N., & Kuppusamy, P. (2010). Crataegus oxycantha extract attenuates apoptotic incidence in myocardial ischemia-reperfusion injury by regulating Akt and HIF-1 signaling pathways. Journal of Cardiovascular Pharmacology, 56(5), 526-531. https://doi.org/10.1097/FJC.0b013e3181f64c51
Jin, A. L., Ozga, J. A., Lopes-Lutz, D., Schieber, A., & Reinecke, D. M. (2012). Characterization of proanthocyanidins in pea (Pisum sativum L.), lentil (Lens culinaris L.), and faba bean (Vicia faba L.) seeds. Food Research International, 46(2), 528-535.
Kapoor, D., Vijayvergiya, R. & Dhawan, V. (2014) ‘Terminalia arjuna in coronary artery disease: Ethnopharmacology, pre-clinical, clinical & safety evaluation’, Journal of Ethnopharmacology, 155(2), pp. 1029–1045. https://doi.org/10.1016/j.jep.2014.06.056
Karthick, M., & Prince, P. S. M. (2006). Preventive effect of rutin, a bioflavonoid, on lipid peroxides and antioxidants in isoproterenol‐induced myocardial infarction in rats. Journal of pharmacy and pharmacology, 58(5), 701-707. https://doi.org/10.1211/jpp.58.5.0016
Kasote, D. M., Katyare, S. S., Hegde, M. V., & Bae, H. (2015). Significance of antioxidant potential of plants and its relevance to therapeutic applications. International journal of biological sciences, 11(8), 982. https://doi.org/10.7150/ijbs.12096
Kawakami, Y., Yamanaka-Okumura, H., Naniwa-Kuroki, Y., Sakuma, M., Taketani, Y., & Takeda, E. (2015). Flaxseed oil intake reduces serum small dense low-density lipoprotein concentrations in Japanese men: a randomized, double blind, crossover study. Nutrition Journal, 14, 1-9.
Khamkar, A.D., Motghare, V. & Deshpande, R. (2015) ‘Ethnopharmacology—a novel approach for drug discovery’, Indian J Pharm Pharmacol, 2(Suppl 4), pp. 222–5.
Khan, J., Deb, P. K., Priya, S., Medina, K. D., Devi, R., Walode, S. G., & Rudrapal, M. (2021). Dietary flavonoids: Cardioprotective potential with antioxidant effects and their pharmacokinetic, toxicological and therapeutic concerns. Molecules, 26(13), 4021. https://doi.org/10.3390/molecules26134021
King, A. & Young, G. (1999) ‘Characteristics and occurrence of phenolic phytochemicals.’, Journal of the American Dietetic Association, 99(2), pp. 213–218. https://doi.org/10.1016/S0002-8223(99)00051-6
Koes, R.E., Quattrocchio, F. & Mol, J.N.M. (1994) ‘The flavonoid biosynthetic pathway in plants: Function and evolution’, BioEssays, 16(2), pp. 123–132. https://doi.org/10.1002/bies.950160209
Kumar, A., Shukla, R., Singh, P., Prasad, C. S., & Dubey, N. K. (2008). Assessment of Thymus vulgaris L. essential oil as a safe botanical preservative against post harvest fungal infestation of food commodities. Innovative food science & emerging technologies, 9(4), 575-580. https://doi.org/10.1016/j.ifset.2007.12.005
Kumari, S., Katare, P. B., Elancheran, R., Nizami, H. L., Paramesha, B., Arava, S., ... & Banerjee, S. K. (2020). Musa balbisiana fruit rich in polyphenols attenuates isoproterenol‐induced cardiac hypertrophy in rats via inhibition of inflammation and oxidative stress. Oxidative medicine and cellular longevity, 2020(1), 7147498. https://doi.org/10.1155/2020/7147498
Lacaille-Dubois, M. A., & Wagner, H. (2000). Bioactive saponins from plants: an update. Studies in natural products chemistry, 21, 633-687. https://doi.org/10.1016/S1572-5995(00)80015-0
Lafay, S. & Gil-Izquierdo, A. (2008) ‘Bioavailability of phenolic acids’, Phytochemistry Reviews, 7(2), pp. 301–311. https://doi.org/10.1007/s11101-007-9077-x
Lampe, J. & Messina, M. (1998) ‘Are phytoestrogens nature’s cure for what ails us? A look at the research. Interview by Nancy I. Hahn.’, Journal of the American Dietetic Association, 98(9), pp. 974–976. https://doi.org/10.1016/s0002-8223(98)00223-5
Lásztity, R., Hidvégi, M. & Bata, Á. (1998) ‘Saponins in food’, Food Reviews International, 14(4), pp. 371–390. https://doi.org/10.1080/87559129809541169
Liu, S., Chang, X., Liu, X., & Shen, Z. (2016). Effects of pretreatments on anthocyanin composition, phenolics contents and antioxidant capacities during fermentation of hawthorn (Crataegus pinnatifida) drink. Food Chemistry, 212, 87-95. https://doi.org/10.1016/j.foodchem.2016.05.146
Mandal, S.M., Chakraborty, D. & Dey, S. (2010) ‘Phenolic acids act as signaling molecules in plant-microbe symbioses’, Plant Signaling & Behavior, 5(4), pp. 359–368. https://doi.org/10.4161/psb.5.4.10871
Moreno, D. A., Ilic, N., Poulev, A., Brasaemle, D. L., Fried, S. K., & Raskin, I. (2003). Inhibitory effects of grape seed extract on lipases. Nutrition, 19(10), 876-879. https://doi.org/10.1016/S0899-9007(03)00167-9
Musazadeh, V., Jafarzadeh, J., Keramati, M., Zarezadeh, M., Ahmadi, M., Farrokhian, Z., & Ostadrahimi, A. (2021). Flaxseed Oil Supplementation Augments Antioxidant Capacity and Alleviates Oxidative Stress: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials. Evidence‐Based Complementary and Alternative Medicine, 2021(1), 4438613. https://doi.org/10.1155/2021/4438613
Nahar, K., Kabir, F., Islam, P., Rahman, M. M., Al Mamun, M. A., Faruk, M., ... & Alam, M. A. (2018). Cardioprotective effect of Amaranthus tricolor extract in isoprenaline induced myocardial damage in ovariectomized rats. Biomedicine & Pharmacotherapy, 103, 1154-1162. https://doi.org/10.1016/j.biopha.2018.04.151
Nowshehri, J.A., Bhat, Z.A. & Shah, M.Y. (2015) ‘Blessings in disguise: Bio-functional benefits of grape seed extracts’, Food Research International, 77, pp. 333–348. https://doi.org/10.1016/j.foodres.2015.08.026
Ononye, S. N., VanHeyst, M. D., Oblak, E. Z., Zhou, W., Ammar, M., Anderson, A. C., & Wright, D. L. (2013). Tropolones as lead-like natural products: the development of potent and selective histone deacetylase inhibitors. ACS medicinal chemistry letters, 4(8), 757-761. https://doi.org/10.1021/ml400158k
Pan, L., Mo, M. Q., Miao, L., Zhang, Q. H., Yang, S., Gao, H., ... & Yin, R. X. (2018). Association of BDNF rs11030104 SNP and serum lipid levels in two Chinese ethnic groups. International Journal of Clinical and Experimental Pathology, 11(3), 1466.
Panda, V. & Shinde, P. (2017) ‘Appetite suppressing effect of Spinacia oleracea in rats: Involvement of the short term satiety signal cholecystokinin.’, Appetite, 113, pp. 224–230. https://doi.org/10.1016/j.appet.2017.02.030
Pawar, R.S. and Bhutani, K.K. (2005) ‘Effect of oleanane triterpenoids from Terminalia arjuna--a cardioprotective drug on the process of respiratory oxyburst.’, Phytomedicine : international journal of phytotherapy and phytopharmacology, 12(5), pp. 391–393. https://doi.org/10.1016/j.phymed.2003.11.007
Pereira, A. & Maraschin, M. (2015) ‘Banana (Musa spp) from peel to pulp: ethnopharmacology, source of bioactive compounds and its relevance for human health.’, Journal of ethnopharmacology, 160, pp. 149–163. https://doi.org/10.1016/j.jep.2014.11.008
Phang, M., Lincz, L.F. & Garg, M.L. (2013) ‘Eicosapentaenoic and docosahexaenoic acid supplementations reduce platelet aggregation and hemostatic markers differentially in men and women.’, The Journal of nutrition, 143(4), pp. 457–463. https://doi.org/10.3945/jn.112.171249
Pittler, M.H., Schmidt, K. & Ernst, E. (2003) ‘Hawthorn extract for treating chronic heart failure: meta-analysis of randomized trials.’, The American journal of medicine, 114(8), pp. 665–674. https://doi.org/10.1016/s0002-9343(03)00131-1
Prasad, K., Khan, A.S. & Shoker, M. (2020) ‘Flaxseed and Its Components in Treatment of Hyperlipidemia and Cardiovascular Disease.’, The International journal of angiology : official publication of the International College of Angiology, Inc, 29(4), pp. 216–222. https://doi.org/10.1055/s-0040-1709129
Ranjbar, K., Zarrinkalam, E., Salehi, I., Komaki, A., & Fayazi, B. (2018). Cardioprotective effect of resistance training and Crataegus oxyacantha extract on ischemia reperfusion–induced oxidative stress in diabetic rats. Biomedicine & Pharmacotherapy, 100, 455-460. https://doi.org/10.1016/j.biopha.2018.02.021
Roy, M., & Datta, A. (2019). Cancer genetics and therapeutics: focus on phytochemicals. Springer Nature.
Sandhu, J. S., Shah, B., Shenoy, S., Chauhan, S., Lavekar, G. S., & Padhi, M. M. (2010). Effects of Withania somnifera (Ashwagandha) and Terminalia arjuna (Arjuna) on physical performance and cardiorespiratory endurance in healthy young adults. International journal of Ayurveda research, 1(3), 144. https://doi.org/10.4103/0974-7788.72485
Saravanan, G. and Ponmurugan, P. (2012) ‘Amaranthus viridis Linn., a common spinach, modulates C-reactive protein, protein profile, ceruloplasmin and glycoprotein in experimental induced myocardial infarcted rats.’, Journal of the science of food and agriculture, 92(12), pp. 2459–2464. https://doi.org/10.1002/jsfa.5652
Sarveswaran, S., Ghosh, R., Parikh, R., & Ghosh, J. (2016). Wedelolactone, an anti-inflammatory botanical, interrupts c-Myc oncogenic signaling and synergizes with enzalutamide to induce apoptosis in prostate cancer cells. Molecular cancer therapeutics, 15(11), 2791-2801. https://doi.org/10.1158/1535-7163.MCT-15-0861
Saxena, M., Saxena, J., Nema, R., Singh, D., & Gupta, A. (2013). Phytochemistry of medicinal plants. Journal of pharmacognosy and phytochemistry, 1(6).
Seto, R., Nakamura, H., Nanjo, F., & Hara, Y. (1997). Preparation of epimers of tea catechins by heat treatment. Bioscience, biotechnology, and biochemistry, 61(9), 1434-1439.
Shah, S. M. A., Akram, M., Riaz, M., Munir, N., & Rasool, G. (2019). Cardioprotective potential of plant-derived molecules: a scientific and medicinal approach. Dose-response, 17(2), 1559325819852243. https://doi.org/10.1177/1559325819852243
Shearman, C. P., Gosling, P., Gwynn, B. R., & Simms, M. H. (1988). Systemic effects associated with intermittent claudication. A model to study biochemical aspects of vascular disease?. European Journal of Vascular Surgery, 2(6), 401-404. https://doi.org/10.1016/S0950-821X(88)80019-7
Sofowora, A., Ogunbodede, E. & Onayade, A. (2013) ‘The role and place of medicinal plants in the strategies for disease prevention.’, African journal of traditional, complementary, and alternative medicines : AJTCAM, 10(5), pp. 210–229. https://doi.org/10.4314/ajtcam.v10i5.2
Springob, K. & Kutchan, T.M. (2009) ‘Introduction to the different classes of natural products’, Plant-derived natural products: Synthesis, function, and application, pp. 3–50.
Srivastava, S.K., Srivastava, S.D. and Chouksey, B.K. (2001) ‘New antifungal constituents from Terminalia alata.’, Fitoterapia, 72(2), pp. 106–112. : https://doi.org/10.1016/s0367-326x(00)00261-6
Stein, J. H., Keevil, J. G., Wiebe, D. A., Aeschlimann, S., & Folts, J. D. (1999). Purple grape juice improves endothelial function and reduces the susceptibility of LDL cholesterol to oxidation in patients with coronary artery disease. Circulation, 100(10), 1050-1055. https://doi.org/10.1161/01.cir.100.10.1050
Subramaniam, S., Ramachandran, S., Uthrapathi, S., Gnamanickam, V. R., & Dubey, G. P. (2011). Anti-hyperlipidemic and antioxidant potential of different fractions of Terminalia arjuna Roxb. bark against PX-407 induced hyperlipidemia. Indian journal of experimental biology, 49(4), pp. 282–288.
Suleiman, K. Y., Ajani, E. O., Biobaku, K. T., Okediran, B. S., Azeez, M. O., Jimoh, G. A., ... & Ahmed, A. O. (2021). Cardioprotective effects of aqueous extract of ripped musa paradisiaca peel in isoproterenol induced myocardial infarction rat model. Biomedical Research and Therapy, 8(10), 4634-4648. https://doi.org/10.15419/bmrat.v8i10.699
Taku, K., Melby, M. K., Nishi, N., Omori, T., & Kurzer, M. S. (2011). Soy isoflavones for osteoporosis: an evidence-based approach. Maturitas, 70(4), 333-338. https://doi.org/10.1016/j.maturitas.2011.09.001
Tanaka, T. & Matsuo, Y. (2020) ‘Production mechanisms of black tea polyphenols’, Chemical and Pharmaceutical Bulletin, 68(12), pp. 1131–1142.
Vijayakumar, S., Presannakumar, G. & Vijayalakshmi, N.R. (2008) ‘Antioxidant activity of banana flavonoids.’, Fitoterapia, 79(4), pp. 279–282. https://doi.org/10.1016/j.fitote.2008.01.007
Walton, N.J., Mayer, M.J. & Narbad, A. (2003) ‘Vanillin.’, Phytochemistry, 63(5), pp. 505–515. https://doi.org/10.1016/s0031-9422(03)00149-3
Wang, X., Ouyang, Y. Y., Liu, J., & Zhao, G. (2014). Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies. British Journal of Nutrition, 111(1), 1-11. https://doi.org/10.1017/S000711451300278X
Wang, Y. D., Zhang, Y., Sun, B., Leng, X. W., Li, Y. J., & Ren, L. Q. (2018). Cardioprotective effects of rutin in rats exposed to pirarubicin toxicity. Journal of Asian Natural Products Research, 20(4), 361-373. https://doi.org/10.1080/10286020.2017.1394292
Wei, P., Liu, M., Chen, Y., & Chen, D. C. (2012). Systematic review of soy isoflavone supplements on osteoporosis in women. Asian Pacific journal of tropical medicine, 5(3), 243-248. https://doi.org/10.1016/S1995-7645(12)60033-9
Wong, Z.W., Thanikachalam, P.V. & Ramamurthy, S. (2017) ‘Molecular understanding of the protective role of natural products on isoproterenol-induced myocardial infarction: A review.’, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 94, pp. 1145–1166. https://doi.org/10.1016/j.biopha.2017.08.009
Yang, G., Wang, Y., Zeng, Y., Gao, G. F., Liang, X., Zhou, M., ... & Murray, C. J. (2013). Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010. The lancet, 381(9882), 1987-2015. https://doi.org/10.1016/S0140-6736(13)61097-1
Yang, L. & Stöckigt, J. (2010) ‘Trends for diverse production strategies of plant medicinal alkaloids’, Natural product reports, 27(10), pp. 1469–1479.
Yilmaz, Y. & Toledo, R.T. (2004) ‘Health aspects of functional grape seed constituents’, Trends in food science & technology, 15(9), pp. 422–433.
Zhang, Y., Zhang, L., Geng, Y., & Geng, Y. (2014). Hawthorn fruit attenuates atherosclerosis by improving the hypolipidemic and antioxidant activities in apolipoprotein e-deficient mice. Journal of atherosclerosis and thrombosis, 21(2), 119-128. https://doi.org/10.5551/jat.19174
Zhu, R., Zhang, X., Wang, Y., Zhang, L., Wang, C., Hu, F., ... & Chen, G. (2019). Pectin oligosaccharides from hawthorn (Crataegus pinnatifida Bunge. Var. major): Molecular characterization and potential antiglycation activities. Food Chemistry, 286, 129-135. https://doi.org/10.1016/j.foodchem.2019.01.215
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