Effect of Vitamin D and Bone Density in Patients with Chronic Hepatitis C
DOI:
https://doi.org/10.5281/zenodo.15773451Abstract
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Hepatitis C virus (HBV) infection is a common health problem that has a worldwide distribution. Apart from the direct effect of the virus on the liver, there are many extrahepatic manifestations among which the probable effect on bone turnover associated with low bone mineral density (BMD) and deficiency of vitamin D. The aim of this study was to investigate the effects of bone mineral metabolism and vitamin D in patients with chronic hepatitis C. This study which included a total of 45 patients with chronic HBV (age range 25–50 years) and 50 healthy people were invited to participate in the present study. Attending Imam Hussein Medical City, Karbala. Biochemical tests included total serum calcium, phosphate, and creatinine and total alkaline phosphatase and vitamin D. Serum concentrations of biochemical bone markers were in the normal range for both CHC patients and controls did not differ significantly in results.
Keywords:
Alkaline phosphatase, Bone mineral density, Creatinine, HepatitisReferences
Baur, K., Mertens, J. C., Schmitt, J., Iwata, R., Stieger, B., Eloranta, J. J., ... & Swiss Hepatitis C Cohort Study Group. (2012). Combined effect of 25‐OH vitamin D plasma levels and genetic V itamin DR eceptor (NR 1I1) variants on fibrosis progression rate in HCV patients. Liver International, 32(4), 635-643. https://doi.org/10.1111/j.1478-3231.2011.02674.x
Bitetto, D., Fabris, C., Fornasiere, E., Pipan, C., Fumolo, E., Cussigh, A., ... & Toniutto, P. (2011). Vitamin D supplementation improves response to antiviral treatment for recurrent hepatitis C. Transplant International, 24(1), 43-50. https://doi.org/10.1111/j.1432-2277.2010.01141.x
Bitetto, D., Fattovich, G., Fabris, C., Ceriani, E., Falleti, E., Fornasiere, E., ... & Toniutto, P. (2011). Complementary role of vitamin D deficiency and the interleukin‐28B rs12979860 C/T polymorphism in predicting antiviral response in chronic hepatitis C. Hepatology, 53(4), 1118-1126. https://doi.org/10.1002/hep.24201
Chen, C. H., Lin, C. L., & Kao, C. H. (2015). Relation between hepatitis C virus exposure and risk of osteoporosis: a nationwide population-based study. Medicine, 94(47), e2086. https://doi.org/10.1097/MD.0000000000002086
Chen, E. Q., Shi, Y., & Tang, H. (2014). New insight of vitamin D in chronic liver diseases. Hepatobiliary & Pancreatic Diseases International, 13(6), 580-585. https://doi.org/10.1016/S1499-3872(14)60295-2
Christakos, S., Dhawan, P., Verstuyf, A., Verlinden, L., & Carmeliet, G. (2016). Vitamin D: metabolism, molecular mechanism of action, and pleiotropic effects. Physiological Reviews, 96(1), 365-408. https://doi.org/10.1152/physrev.00014.2015
Cosman, F., Morgan, D. C., Nieves, J. W., Shen, V., Luckey, M. M., Dempster, D. W., ... & Parisien, M. (1997). Resistance to bone resorbing effects of PTH in black women. Journal of Bone and Mineral Research, 12(6), 958-966. https://doi.org/10.1359/jbmr.1997.12.6.958
Duarte, M. P., Farias, M. L. F., Coelho, H. S. M., Mendonca, L. M., Stabnov, L. M., Oliveira, M. D. C. D., ... & Oliveira, D. S. (2001). Calcium‐parathyroid hormone‐vitamin D axis and metabolic bone disease in chronic viral liver disease. Journal of Gastroenterology and Hepatology, 16(9), 1022-1027. https://doi.org/10.1046/j.1440-1746.2001.02561.x
El-Maouche, D., Mehta, S. H., Sutcliffe, C. G., Higgins, Y., Torbenson, M. S., Moore, R. D., ... & Brown, T. T. (2013). Vitamin D deiciency and its relation to bone mineral density and liver ibrosis in HIV-HCV coinfection. Antiviral Therapy, 18(2), 237-242. https://doi.org/10.3851/IMP2264
Hofmann, W. P., Kronenberger, B., Bojunga, J., Stamm, B., Herrmann, E., Bücker, A., ... & Sarrazin, C. (2008). Prospective study of bone mineral density and metabolism in patients with chronic hepatitis C during pegylated interferon α and ribavirin therapy. Journal of Viral Hepatitis, 15(11), 790-796. https://doi.org/10.1111/j.1365-2893.2008.01038.x
Høiberg, M., Nielsen, T. L., Wraae, K., Abrahamsen, B., Hagen, C., Andersen, M., & Brixen, K. (2007). Population-based reference values for bone mineral density in young men. Osteoporosis International, 18, 1507-1514. https://doi.org/10.1007/s00198-007-0399-8
Hu, D. J., Kane, M. A., & Heymann, D. L. (1991). Transmission of HIV, hepatitis B virus, and other bloodborne pathogens in health care settings: a review of risk factors and guidelines for prevention. World Health Organization. Bulletin of the World Health Organization, 69(5), 623. https://pubmed.ncbi.nlm.nih.gov/1959164/
Huang, Z., Wei, H., Cheng, C., Yang, S., Wang, J., & Liu, X. (2017). Low bone mineral density in chronic hepatitis B virus infection: A case-control study. Pakistan Journal of Medical Sciences, 33(2), 457. https://doi.org/10.12669/pjms.332.12099
Khosla, S., Hassoun, A. A., Baker, B. K., Liu, F., Zein, N. N., Whyte, M. P., ... & Conover, C. A. (1998). Insulin-like growth factor system abnormalities in hepatitis C-associated osteosclerosis. Potential insights into increasing bone mass in adults. The Journal of Clinical Investigation, 101(10), 2165-2173. https://doi.org/10.1172/JCI1111
Kitson, M. T., & Roberts, S. K. (2012). D-livering the message: the importance of vitamin D status in chronic liver disease. Journal of Hepatology, 57(4), 897-909. https://doi.org/10.1016/j.jhep.2012.04.033
Lange, C. M., Bojunga, J., Ramos-Lopez, E., von Wagner, M., Hassler, A., Vermehren, J., ... & Sarrazin, C. (2011). Vitamin D deficiency and a CYP27B1-1260 promoter polymorphism are associated with chronic hepatitis C and poor response to interferon-alfa based therapy. Journal of Hepatology, 54(5), 887-893. https://doi.org/10.1016/j.jhep.2010.08.036
Mandorfer, M., Reiberger, T., Payer, B. A., Ferlitsch, A., Breitenecker, F., Aichelburg, M. C., ... & Vienna HIV & Liver Study Group. (2013). Low vitamin D levels are associated with impaired virologic response to PEGIFN+ RBV therapy in HIV–hepatitis C virus coinfected patients. Aids, 27(2), 227-232. https://doi.org/10.1097/QAD.0b013e32835aa161
Necati, Y. E. N., CE, M. G., & Özgür MEHTAP, A. K. (2006). Assessment of bone metabolism and mineral density in chronic viral hepatitis. Turk J Gastroenterol, 17(4), 260-266.
Petta, S., Cammà, C., Scazzone, C., Tripodo, C., Di Marco, V., Bono, A., ... & Craxí, A. (2010). Low vitamin D serum level is related to severe fibrosis and low responsiveness to interferon‐based therapy in genotype 1 chronic hepatitis C. Hepatology, 51(4), 1158-1167. https://doi.org/10.1002/hep.23489
Rosen C. J. (2011). Clinical practice. Vitamin D insufficiency. The New England journal of medicine, 364(3), 248–254. https://doi.org/10.1056/NEJMcp1009570
Schiefke, I., Fach, A., Wiedmann, M., Aretin, A. V., Schenker, E., Borte, G., ... & Moessner, J. (2005). Reduced bone mineral density and altered bone turnover markers in patients with non-cirrhotic chronic hepatitis B or C infection. World Journal of Gastroenterology: WJG, 11(12), 1843. https://doi.org/10.3748/wjg.v11.i12.1843
Schwartz, K. M., & Skinner, J. A. (2008). Hepatitis C-associated osteosclerosis: a case report. Skeletal Radiology, 37(7), 679-681. https://doi.org/10.1007/s00256-008-0471-2
Taksler, G. B., Cutler, D. M., Giovannucci, E., & Keating, N. L. (2015). Vitamin D deficiency in minority populations. Public Health Nutrition, 18(3), 379-391. https://doi.org/10.1017/S1368980014000457
Tanaka, T., Latorre, M. R. D. O., Jaime, P. C., Florindo, A. A., Pippa, M. G. B., & Zerbini, C. A. F. (2001). Risk factors for proximal femur osteoporosis in men aged 50 years or older. Osteoporosis International, 12, 942-949. https://doi.org/10.1007/s001980170023
Terrier, B., Carrat, F., Geri, G., Pol, S., Piroth, L., Halfon, P., ... & Cacoub, P. (2011). Low 25-OH vitamin D serum levels correlate with severe fibrosis in HIV-HCV co-infected patients with chronic hepatitis. Journal of Hepatology, 55(4), 756-761. https://doi.org/10.1016/j.jhep.2011.01.041
Trépo, E., Ouziel, R., Pradat, P., Momozawa, Y., Quertinmont, E., Gervy, C., ... & Moreno, C. (2013). Marked 25-hydroxyvitamin D deficiency is associated with poor prognosis in patients with alcoholic liver disease. Journal of Hepatology, 59(2), 344-350. https://doi.org/10.1016/j.jhep.2013.03.024
Yokoyama, S., Takahashi, S., Kawakami, Y., Hayes, C. N., Kohno, H., Kohno, H., ... & Chayama, K. (2014). Effect of vitamin D supplementation on pegylated interferon/ribavirin therapy for chronic hepatitis C genotype 1b: a randomized controlled trial. Journal of Viral Hepatitis, 21(5), 348-356. https://doi.org/10.1111/jvh.12146
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