Expression of MacAB-TolC and MdfA Efflux Pumps in Associated with Multi Drug Resistant Salmonella Enterica Serovar Typhi Isolates
DOI:
https://doi.org/10.5281/zenodo.15284826Abstract
Abstract Views: 215
Salmonella Typhi is the cause of typhoid fever. Together, Salmonella Typhi and Salmonella serovar Paratyphi A are the major agents of enteric fever. Typhoid fever affects millions of individuals each year in low-income nations. Human infection severity is determined by infectious doses and organism pathogenicity. Bacterial membrane and periplasm transporter proteins construct this barrier. These proteins remove antimicrobials, organic solvents, and toxic heavy metals from bacterial cells. Overexpression of the macAB-TolC genes induces macrolide resistance in Salmonella enterica. Salmonella pathogenicity is reduced in mice by macAB-TolC gene deletion. Due to its ability to expel structurally unrelated drugs. MdfA, a single cytoplasmic efflux protein, exports antibiotics when overexpressed.
Keywords:
Efflux pump, MacAB-TolC, Mdf A, MDR, Salmonella Typhi, XDRReferences
Al-Rhman, R. M. A., AlSAffar, J. M. J., Mater, H. N., & Mahmood, M. S. (2021). Diagnosis Infection of Salmonella Typhi. Annals of the Romanian Society for Cell Biology, 25(6), 11918-11922.
Shah, S. R. (2021). Salmonella typhi as a Pathogenic Organism----A Mini Review. Pak-Euro Journal of Medical and Life Sciences, 4(Special Is), S105-S110.
Takaya, A., Yamamoto, T., & Tokoyoda, K. (2020). Humoral immunity vs. Salmonella. Frontiers in Immunology, 10, 3155. https://doi.org/10.3389/fimmu.2019.03155
Crump, J. A., Sjölund-Karlsson, M., Gordon, M. A., & Parry, C. M. (2015). Epidemiology, clinical presentation, laboratory diagnosis, antimicrobial resistance, and antimicrobial management of invasive Salmonella infections. Clinical microbiology reviews, 28(4), 901-937. https://doi.org/10.1128/cmr.00002-15
Watkins, L. K. F., Winstead, A., Appiah, G. D., Friedman, C. R., Medalla, F., Hughes, M. J., ... & Mintz, E. (2020). Update on extensively drug-resistant Salmonella serotype Typhi infections among travelers to or from Pakistan and report of ceftriaxone-resistant Salmonella serotype Typhi infections among travelers to Iraq—United States, 2018–2019. Morbidity and Mortality Weekly Report, 69(20), 618. https://doi.org/10.15585/mmwr.mm6920a2
Akram, J., Khan, A. S., Khan, H. A., Gilani, S. A., Akram, S. J., Ahmad, F. J., & Mehboob, R. (2020). Extensively drug-resistant (XDR) typhoid: evolution, prevention, and its management. BioMed Research International, 2020. https://doi.org/10.1155/2020/6432580
Rana, S., Maurya, S., Chadrasekhar, H., & Srikanth, C. V. (2021). Molecular determinants of peaceful coexistence versus invasiveness of non-Typhoidal Salmonella: Implications in long-term side-effects. Molecular Aspects of Medicine, 81, 100997. https://doi.org/10.1016/j.mam.2021.100997
Magiorakos, A. P., Srinivasan, A., Carey, R. B., Carmeli, Y., Falagas, M. E., Giske, C. G., ... & Monnet, D. L. (2012). Multidrug-resistant, extensively drug-resistant and pandrug-resistant bacteria: an international expert proposal for interim standard definitions for acquired resistance. Clinical microbiology and infection, 18(3), 268-281. https://doi.org/10.1111/j.1469-0691.2011.03570.x
Saha, S., Sajib, M. S. I., Garrett, D., & Qamar, F. N. (2020). Antimicrobial resistance in typhoidal salmonella: Around the world in 3 days. Clinical Infectious Diseases, 71(Supplement_2), S91-S95. https://doi.org/10.1093/cid/ciaa366
Godbole, G., McCann, N., Jones, S. M., Dallman, T. J., & Brown, M. (2019). Ceftriaxone-resistant Salmonella Typhi in a traveller returning from a mass gathering in Iraq. The Lancet Infectious Diseases, 19(5), 467. https://doi.org/10.1016/s1473-3099(19)30176-8
Gong, B., Li, H., Feng, Y., Zeng, S., Zhuo, Z., Luo, J., ... & Li, X. (2022). Prevalence, serotype distribution and antimicrobial resistance of non-typhoidal Salmonella in hospitalized patients in Conghua District of Guangzhou, China. Frontiers in Cellular and Infection Microbiology, 12, 805384. https://doi.org/10.3389/fcimb.2022.805384
Qamar, F. N., Yousafzai, M. T., Khalid, M., Kazi, A. M., Lohana, H., Karim, S., ... & Hasan, R. (2018). Outbreak investigation of ceftriaxone-resistant Salmonella enterica serotype Typhi and its risk factors among the general population in Hyderabad, Pakistan: a matched case-control study. The Lancet Infectious Diseases, 18(12), 1368-1376. https://doi.org/10.1016/s1473-3099(18)30483-3
Wójcicki, M., Chmielarczyk, A., Świder, O., Średnicka, P., Strus, M., Kasperski, T., ... & Juszczuk-Kubiak, E. (2022). Bacterial Pathogens in the Food Industry: Antibiotic Resistance and Virulence Factors of Salmonella enterica Strains Isolated from Food Chain Links. Pathogens, 11(11), 1323. https://doi.org/10.3390/pathogens11111323
Sun, J., Deng, Z., & Yan, A. (2014). Bacterial multidrug efflux pumps: mechanisms, physiology and pharmacological exploitations. Biochemical and biophysical research communications, 453(2), 254-267. https://doi.org/10.1016/j.bbrc.2014.05.090
Kobayashi, N., Nishino, K., & Yamaguchi, A. (2001). Novel macrolide-specific ABC-type efflux transporter in Escherichia coli. Journal of bacteriology, 183(19), 5639-5644. https://doi.org/10.1128/jb.183.19.5639-5644.2001
Jo, I., Hong, S., Lee, M., Song, S., Kim, J. S., Mitra, A. K., ... & Ha, N. C. (2017). Stoichiometry and mechanistic implications of the MacAB-TolC tripartite efflux pump. Biochemical and biophysical research communications, 494(3-4), 668-673. https://doi.org/10.1016/j.bbrc.2017.10.102
Horiyama, T., Yamaguchi, A., & Nishino, K. (2010). TolC dependency of multidrug efflux systems in Salmonella enterica serovar Typhimurium. Journal of antimicrobial chemotherapy, 65(7), 1372-1376. https://doi.org/10.1093/jac/dkq160
Das, S., Ray, U., Akhter, I., Chattopadhyay, A., Paul, D. K., & Dutta, S. (2016). Evaluation of fliC-d based direct blood PCR assays for typhoid diagnosis. BMC microbiology, 16(1), 1-8. https://doi.org/10.1186/s12866-016-0723-6
Khan, S., Harish, B. N., Menezes, G. A., Acharya, N. S., & Parija, S. C. (2012). Early diagnosis of typhoid fever by nested PCR for flagellin gene of Salmonella enterica serotype Typhi. Indian Journal of Medical Research, 136(5), 850-854.
Bunyan, I. A., & Obeis, A. A. (2019). Molecular study about some genes among salmonella Typhi isolates un Hilla/Iraq. International Journal of Drug Delivery Technology, 9(2), 264-271. https://doi.org/10.25258/ijddt.9.2.24
Salazar-Gonzalez, R. M., & McSorley, S. J. (2005). Salmonella flagellin, a microbial target of the innate and adaptive immune system. Immunology letters, 101(2), 117-122. https://doi.org/10.1016/j.imlet.2005.05.004
Medhat, A. R., & Aljanabay, A. A. J. (2022). Epidemiology of typhoid fever in Balad City, Iraq. International Journal of Health Sciences, 6(1), 1049-1063. https://doi.org/10.53730/ijhs.v6ns1.4834
Paul, U. K., & Bandyopadhyay, A. (2017). Typhoid fever: a review. International Journal of Advances in Medicine, 4(2), 300.
Abd Al Mayahi, F. S., & Jaber, S. M. (2020). A preliminary study of multiple antibiotic resistance (MAR) and extensively drug-resistant (XDR) of bacterial causing typhoid fever isolated from stool specimens in Al-Diwaniya, Iraq. EurAsian Journal of BioSciences, 14(1). https://doi.org/10.54319/jjbs/140414
Salman, H. A., Abdulmohsen, A. M., Falih, M. N., & Romi, Z. M. (2021). Detection of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi isolated from Iraqi subjects. Veterinary world, 14(7), 1922. https://doi.org/10.14202/vetworld.2021.1922-1928
Yang, C., Li, H., Zhang, T., Chu, Y., Zuo, J., & Chen, D. (2020). Study on antibiotic susceptibility of Salmonella Typhimurium L forms to the third and forth generation cephalosporins. Scientific reports, 10(1), 3042. https://doi.org/10.1038/s41598-020-59456-8
Abd Al Mayahi, F. S., & Jaber, S. M. (2020). A preliminary study of multiple antibiotic resistance (MAR) and extensively drug-resistant (XDR) of bacterial causing typhoid fever isolated from stool specimens in Al-Diwaniya, Iraq. EurAsian Journal of BioSciences, 14(1). https://doi.org/10.54319/jjbs/140414
Salman, H. A., Abdulmohsen, A. M., Falih, M. N., & Romi, Z. M. (2021). Detection of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi isolated from Iraqi subjects. Veterinary world, 14(7), 1922. https://doi.org/10.14202/vetworld.2021.1922-1928
Perera, N., Geary, C., Wiselka, M., Rajakumar, K., & Andrew Swann, R. (2007). Mixed Salmonella infection: case report and review of the literature. Journal of travel medicine, 14(2), 134-135. https://doi.org/10.1111/j.1708-8305.2007.00111.x
Reed, M. D. (1998). Rational prescribing of extended-spectrum penicillin β-lactamase inhibitor combinations: focus on ticarcillin/clavulanic acid. Annals of Pharmacotherapy, 32(1), S17-S21. https://doi.org/10.1177/106002809803200105
Salman, H. A., Abdulmohsen, A. M., Falih, M. N., & Romi, Z. M. (2021). Detection of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi isolated from Iraqi subjects. Veterinary world, 14(7), 1922. https://doi.org/10.14202/vetworld.2021.1922-1928
Abd Al Mayahi, F. S., & Jaber, S. M. (2020). A preliminary study of multiple antibiotic resistance (MAR) and extensively drug-resistant (XDR) of bacterial causing typhoid fever isolated from stool specimens in Al-Diwaniya, Iraq. EurAsian Journal of BioSciences, 14(1). https://doi.org/10.54319/jjbs/140414
Mutai, W.C., Muigai, A.W.T., Waiyaki, P. and Kariuki, S. (2018) Multi-drug resistant Salmonella enterica serovar Typhi isolates with reduced susceptibility to ciprofloxacin in Kenya. BMC Microbiol., 18(1): 187. https://doi.org/10.1186/s12866-018-1332-3
Date, K. A., Newton, A. E., Medalla, F., Blackstock, A., Richardson, L., &et al (2016). Changing patterns in enteric fever incidence and increasing antibiotic resistance of enteric fever isolates in the United States, 2008–2012. Reviews of Infectious Diseases, 63(3), 322-329. https://doi.org/10.1093/cid/ciw232
Tosisa, W., Mihret, A., Ararsa, A., Eguale, T., & Abebe, T. (2020). Prevalence and antimicrobial susceptibility of Salmonella and Shigella species isolated from diarrheic children in Ambo town. BMC pediatrics, 20(1), 1-8. https://doi.org/10.1186/s12887-020-1970-0
Rahman, B. A., Wasfy, M. O., Maksoud, M. A., Hanna, N., Dueger, E., & House, B. (2014). Multi-drug resistance and reduced susceptibility to ciprofloxacin among Salmonella enterica serovar Typhi isolates from the Middle East and Central Asia. New microbes and new infections, 2(4), 88-92. https://doi.org/10.1002/nmi2.46
Rasool, K.H., Hussein, N.H. and Taha, B.M. (2020) Molecular detection of gyrA gene in Salmonella enterica serovar Typhi isolated from typhoid patients in Baghdad. Pak. J. Biolog. Sci., 23(10): 1303-1309. https://doi.org/10.3923/pjbs.2020.1303.1309
Lugito, N. P. H. (2017). Antimicrobial resistance of Salmonella enterica serovars Typhi and Paratyphi isolates from a general hospital in Karawaci, Tangerang, Indonesia: A five-year review. International Journal of Microbiology, 2017. https://doi.org/10.1155/2017/6215136
Chand, H. J., Rijal, K. R., Neupane, B., Sharma, V. K., & Jha, B. (2014). Re-emergence of susceptibility to conventional first line drugs in Salmonella isolates from enteric fever patients in Nepal. The Journal of Infection in Developing Countries, 8(11), 1483-1487. https://doi.org/10.3855/jidc.4228
Garrido‐Mesa, N., Zarzuelo, A., & Gálvez, J. (2013). Minocycline: far beyond an antibiotic. British journal of pharmacology, 169(2), 337-352. https://doi.org/10.1111/bph.12139
Cha, S. Y., Kang, M., Yoon, R. H., Park, C. K., Moon, O. K., & Jang, H. K. (2013). Prevalence and antimicrobial susceptibility of Salmonella isolates in Pekin ducks from South Korea. Comparative Immunology, Microbiology and Infectious Diseases, 36(5), 473-479. https://doi.org/10.1016/j.cimid.2013.03.004
Radhakrishnan, A., Als, D., Mintz, E. D., Crump, J. A., Stanaway, J., Breiman, R. F., & Bhutta, Z. A. (2018). Introductory article on global burden and epidemiology of typhoid fever. The American journal of tropical medicine and hygiene, 99(3 Suppl), 4. https://doi.org/10.4269/ajtmh.18-0032
Abd Al Mayahi, F. S., & Jaber, S. M. (2020). A preliminary study of multiple antibiotic resistance (MAR) and extensively drug-resistant (XDR) of bacterial causing typhoid fever isolated from stool specimens in Al-Diwaniya, Iraq. EurAsian Journal of BioSciences, 14(1). https://doi.org/10.54319/jjbs/140414
Salman, H. A., Abdulmohsen, A. M., Falih, M. N., & Romi, Z. M. (2021). Detection of multidrug-resistant Salmonella enterica subsp. enterica serovar Typhi isolated from Iraqi subjects. Veterinary world, 14(7), 1922. https://doi.org/10.14202/vetworld.2021.1922-1928
Shetty, A.K., Shetty, I.N., Furtado, Z.V., Antony, B. andBoloor, R. (2012) Antibiogram of Salmonella isolates fromblood with an emphasis on nalidixic Acid and chloramphenicol susceptibility in a tertiary care hospital in coastalKarnataka: A prospective study. J. Lab. Physicians, 4(2):74-77. https://doi.org/10.4103/0974-2727.105585
Chand, H.J., Rijal, K.R., Neupane, B., Sharma, V.K. andJha, B. (2014) Re-emergence of susceptibility to conventional first line drugs in Salmonella isolates from entericfever patients in Nepal. J. Infect. Dev. Ctries., 8(11):1483-1487. https://doi.org/10.3855/jidc.4228
Abdelhamid, S. M., & Abozahra, R. R. (2017). Expression of the Fluoroquinolones Efflux Pump Genes A and A in Urinary Isolates. Polish Journal of Microbiology, 66(1), 25-30. https://doi.org/10.5604/17331331.1234990
Ferrari, R. G., Galiana, A., Cremades, R., Rodríguez, J. C., Magnani, M., &et al (2013). Expression of the marA, soxS, acrB and ramA genes related to the AcrAB/TolC efflux pump in Salmonella enterica strains with and without quinolone resistance-determining regions gyrA gene mutations. The Brazilian Journal of Infectious Diseases, 17(2), 125-130. https://doi.org/10.1016/j.bjid.2012.09.011
Iyer, R., Moussa, S. H., Tommasi, R., & Miller, A. A. (2019). Role of the Klebsiella pneumoniae TolC porin in antibiotic efflux. Research in microbiology, 170(2), 112-116. https://doi.org/10.1016/j.resmic.2018.11.003
Tirosh, O. (2014). Functional and Structural Studies of the Secondary Transporter MdfA, an Escherichia coli Proton/Multidrug Antiporter (Doctoral dissertation, The Weizmann Institute of Science (Israel)).
Paltansing, S., Tengeler, A. C., Kraakman, M. E., Claas, E. C., & Bernards, A. T. (2013). Exploring the contribution of efflux on the resistance to fluoroquinolones in clinical isolates of Escherichia coli. Microbial drug resistance, 19(6), 469-476. https://doi.org/10.1089/mdr.2013.0058
Abdelhamid, S. M., & Abozahra, R. R. (2017). Expression of the Fluoroquinolones Efflux Pump Genes A and A in Urinary Isolates. Polish Journal of Microbiology, 66(1), 25-30. https://doi.org/10.5604/17331331.1234990
Neuberger, A., Du, D., & Luisi, B. F. (2018). Structure and mechanism of bacterial tripartite efflux pumps. Research in microbiology, 169(7-8), 401-413. https://doi.org/10.1016/j.resmic.2018.05.003
Chen, Y. J., Pornillos, O., Lieu, S., Ma, C., Chen, A. P., & Chang, G. (2007). X-ray structure of EmrE supports dual topology model. Proceedings of the National Academy of Sciences, 104(48), 18999-19004. https://doi.org/10.1073/pnas.0709387104
Crow, A., Greene, N. P., Kaplan, E., and Koronakis, V. (2017). Structure and mechanotransmission mechanism of the MacB ABC transporter superfamily. Proc. Natl. Acad. Sci. U.S.A. 114, 12572–12577. https://doi.org/10.1073/pnas.1712153114
Lin, Y. T., Huang, Y. W., Liou, R. S., Chang, Y. C., & Yang, T. C. (2014). MacABCsm, an ABC-type tripartite efflux pump of Stenotrophomonas maltophilia involved in drug resistance, oxidative and envelope stress tolerances and biofilm formation. Journal of Antimicrobial Chemotherapy, 69(12), 3221-3226. https://doi.org/10.1093/jac/dku317
Rouquette-Loughlin, C. E., Balthazar, J. T., and Shafer, W. M. (2005). Characterization of the MacA-MacB efflux system in Neisseria gonorrhoeae. J. Antimicrob. Chemother. 56, 856–860. https://doi.org/10.1093/jac/dki333
Henry, R., Vithanage, N., Harrison, P., Seemann, T., Coutts, S., Moffatt, J. H., ... & Boyce, J. D. (2012). Colistin-resistant, lipopolysaccharide-deficient Acinetobacter baumannii responds to lipopolysaccharide loss through increased expression of genes involved in the synthesis and transport of lipoproteins, phospholipids, and poly-β-1, 6-N-acetylglucosamine. Antimicrobial agents and chemotherapy, 56(1), 59-69. https://doi.org/10.1128/aac.05191-11
Lin, H.-T. V., Massam-Wu, T., Lin, C.-P., Wang, Y.-J. A., Shen, Y.-C., Lu, W.-J., et al. (2017). The Vibrio cholerae var regulon encodes a metallo-β-lactamase and an antibiotic efflux pump, which are regulated by VarR, a LysR-type transcription factor. PLoS ONE 12:e0184255. https://doi.org/10.1371/journal.pone.0184255
Hamed, Y., Mohammed, B., & Tothli, K. (2022). Conventional and Molecular Diagnosisof Salmonella typhi isolated from Iraqi Patients with Typhoid Fever. Indian Journal of Ecology, 49(18), 493-499.
Sadiq, M. S., & Othman, R. M. (2022). Phylogenetic tree constructed of Salmonella enterica subspecies enterica isolated from animals and humans in Basrah and Baghdad governorates, Iraq. Iraqi Journal of Veterinary Sciences, 36(4), 895-903. https://doi.org/10.33899/ijvs.2022.132478.2096
Bunyan, I. A., & Obeis, A. A. (2020). Sequencing of the SdiA1 amplicons among Salmonella typhi isolated from patients with typhoid fever, Iraq. Plant Archives (09725210), 20(1).
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